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Or, systems tend to sacrifice the periphery to save the core and the core of this system is rotten. We will learn to live outside the system, it will be harder but relationships with people will be strengthened and we will be happier.
Rototillerman,
“23/The question for all that is how an IM injection can lead to LNP/mRNA or spike proteins into the circulatory system. Some Doctors say its not possible, they are too big but don’t mention Transcytosis“
Sweet. This will be helpful. I believe this to be the orthodoxy/dogma among most scientists and doctors therefore it’s not getting the scrutiny it should. Thanks.
It is interesting, I was listening to a podcast of a Dr. (I believe he was from South Africa) who successfully treated covid patients with combination of steroids, antihistamines and aspirin. His trigger for aggressive treatment was shortness of breath and low oxygen. He was treating on the basis that it was systemic allergic response to the spike protein.
It reminded me of when my son was young and the Doc told us that we had take him out of school because she was running out of options to control his asthma and chronic infections. I remember reading about JFK health issues and how cortisone negatively impacted his health. I further researched this only to come to the realization that we may have permanently damaged his immune system since prednisone was the go to medication to get the asthma under control. After realizing this we found alternate ways to support his immune system. In high school, he was still missing 30 days a year due to sickness. Finally, it started to taper in college. Its been a long twenty years but his immune system is function normally now.
So a friend of ours was recently hospitalized with Covid. We offered her IVM, but she was leery about it. She got scared as her symptoms worsened and she went to the ER and was admitted. We told her to ask for antibodies and they said the Biden administration was rationing them and they didn’t have any in the moment. We told her not to go on Remdesivir, she didn’t. Told to ask for D,C, zinc. they did do that and they put her on steroids and oxygen and she is out of the woods and back home.
As I revisit this, it turns out steroids are able to suppress NK cytotoxicity, which must be suppressing the storm that is associated with a severe case. Things that make you go Hmmmm.
DarkMatter,
Nearly everyone was not at risk of a serious inflection in the first place. For those that were, most or them would have been spared hospitalization and death with access to very affordable therapeutics. The injections are worthless and damage the immune system.
Susmarie108,
Nice, they are unaware of the new dawn arising.
But hey, “Biden is a wanker and wears a wanker’s hat”. It’s going to be awhile before I purge that one from my memory. Damn you Polder (with fist in the air)
teri, That was their statement to us. It appears our company’s seniors are playing loose, so I will call them out on that as part of the exemption I submit. I just want to be sure I am on firm ground as they likely to pick off the low hanging fruit if they are planning to be selective. Sorry, I wasn’t being clear. Thanks
Doc,
From my notes (Dr. Mobeen Syed)
1273 amino acids are needed to assemble a spike
One cellular spike factory can produce 6 amino acids per minute
One spike is produced every 4 minutes
Upper limit of 150 million spike proteins for 10 million ribosomes
Life of spike factory from minutes to days, nobody knows.
Japanese bio distribution study gives an idea of how many of these factories might be circulating in our blood stream as a function of time.
Only a fraction of those spikes get expressed on the surface. So do they explode as the factory cell breaks down, getting carried anywhere and everywhere the blood travels painting a cell for eventual T-cell attack?
If anybody wants to run with this, please do. Other priorities are needing my attention and it will be a bit before I can focus on this.
Great, thanks Doc, I am working on how many spike proteins can be manufactured in the event ‘let’s say’ a freshly minted immature dendritic cell links up with an LNP in the bloodstream. Given that there is 10 million ribosomes now available to a single mRNA strand, (as you point out) a shed load of spike can be produced by just one cell. This should get interesting.
Also, I can see where they might argue an onerous burden. For instance, if they wanted me to participate in a meeting or program that involved a branch of the government and I didn’t have the proper papers. Which is really the end game.
teri, thanks for digging deep into this. Your efforts are appreciated. But here is the thing, I work for publicly traded company. Yes, we do have packages of work that are tied to programs that are funded by the government. I am obviously not a federal employee or a contracted employee of the government. If I am interpreting this correctly, I simply work for a soulless corporation that is afraid of losing current government programs or jeopardizing future program wins. Am I missing something in the fine print? Not sure.
Dr. D, when I quote you and people ask I will respond “Haven’t you read the Dr. D translation?” Nice, I like the innocent dove reference. All and all spoken like a wise serpent (Matt. 10:16)
upstateNYer,
Well said, facts/data are no respecter of persons. It up to us to discern irrespective of the source whether we are being intentionally deceived. The formula that Chirpractor=untruth and medical doctor=truth is for the lazy minded.
Timely links (thanks Raul), they will be useful in formulating my exemption request that we can begin submitting come Monday.
I am looking for the estimation of the number of mRNA instructions (spikes) in a jab. Much appreciation to anyone that can link me to this info.
teri,
This is the basis for our companies move to mandate the jabs.
“On September 9, President Biden issued an Executive Order mandating Covid-19 safety protocols for federal contractors. On September 24, the government issued clarifying guidance and, in short, it requires that employees of covered federal contractors be fully vaccinated by December 8, 2021 and to submit proof of vaccination. This guidance has been incorporated through a Federal Acquisition Regulation that will be included in our U.S. government contracts starting October 15, making it both a legal and contractual obligation of the company.”
Anyway, the guys I work with are coming up bagel as to the existence of an EO. Here are a couple articles that hilight it’s non existence.
Joe Biden’s Vaccine Mandate Doesn’t Exist. It’s Just A Press Release.
Americans are no longer living under representative government. We are living under government by the screen people, of the screen people, for the screen people.
By Joy Pullmann
Yes, we’ve heard all about Joe Biden’s alleged vaccine mandate for private companies employing 100 or more people. It was all over the news even before he announced it on September 9. His announcement has jeopardized the employment of millions of Americans and increased worker shortages in critical domains such as health care.
There’s only one problem. It’s all a mirage. Biden’s so-called vaccine mandate doesn’t exist — at least, not yet. So far, all we have is his press conference and other such made-for-media huff-puffing. No such rule even claiming to be legally binding has been issued yet.
That’s why nearly two dozen Republican attorneys general who have publicly voiced their opposition to the clearly unconstitutional and illegal mandate haven’t yet filed suit against it, the Office of the Indiana Attorney General confirmed for me. There is no mandate to haul into court. And that may be part of the plan.
According to several sources, so far it appears no such mandate has been sent to the White House’s Office of Information and Regulatory Affairs yet for approval. The White House, the Occupational Safety and Health Administration (OSHA), and the Department of Labor haven’t released any official guidance for the alleged mandate. There is no executive order. There’s nothing but press statements.
Despite what you may have been falsely led to believe by the media fantasy projection machine, press statements have exactly zero legal authority.
“There is nothing there yet that gives employers any mandate,” Stephanie McFarland, spokeswoman for the Indiana Occupational Safety and Health Administration, told me Oct. 6. “The president made an announcement on this asking OSHA to do it, but we’ve not yet seen anything come from it yet,” she also said. When the state agency gets any further information, she said, they’ll review it.
To impose the public perception of a mandate, the Biden administration is following an unusual rule-making process it also employed earlier this year, called an emergency temporary standard (ETS). The spring ETS rule took nearly six months to issue. Meanwhile, companies are telling reporters their vaccine mandates will have at the latest December deadlines. (For those who can’t calendar, that’s four months after Biden’s non-existent mandate was proclaimed. According to OSHA, an ETS takes up to six months to go into effect after the initial mandate is issued in the Federal Register — which, again, for the proclaimed 100-employee mandate hasn’t happened yet.)
Lawyers for big business were blunt about their love for this mandate mirage: “Everybody loves this cover,” Minneapolis employment lawyer Kate Bischoff told Bloomberg Law in September. “Many were already looking down the road at doing this, but the fact that they get to blame Biden is like manna from heaven.”
Using the ETS procedure instead of normal federal rule-making processes both allows the Biden administration to push its demands faster and without any public input or requirement of responding to public input, which is normally required of even legally laughable federal rule-making like this one would be. That is part of why ETS rules have been overwhelmingly overturned in courts.
…”
Biden Keeps Pushing Nonexistent Worker Vaccine Mandate, A Ploy That Keeps State Attorney Generals From Filing Lawsuits
October 7, 2021 | Sundance
Joe Biden did it again today. A month after the first announcement, the White House occupant claimed again a Dept. of Labor rule (via OSHA) is forthcoming, yet no such process appears to be taking place. This ploy now seems very purposeful because without an actual policy or regulation visibly in place state attorney generals cannot file a lawsuit or request an injunction.
As long as Biden keeps threatening a DOL worker vaccination rule sometime in the future, many employers will take action to require worker vaccination. This seems to be the actual strategy; bolstered by White House Press Secretary Jen Psaki caught off-guard last week when asked about it.
Psaki had no idea how to answer the question about any OSHA activity not taking place (link). Obviously Psaki didn’t expect the question, but it was also obvious that no background conversation had ever taken place amid the White House communication team.
Perhaps responding to an awakening on that issue, Joe Biden gave a speech today begging people to get vaccinated and again warning that a federal vaccine mandate for all workers was coming:
TRANSCRIPT – […] The Labor Department is going to shortly issue an emergency rule — which I asked for several weeks ago, and they’re going through the process — to require all employees [employers] with more than 100 people, whether they work for the federal government or not — this is within a — in the purview of the Labor Department — to ensure their workers are fully vaccinated or face testing at least once a week.
In total, this Labor Department vaccination requirement will cover 100 million Americans, about two thirds of all the people who work in America.
These requirements work.
[…] And as the Business Roundtable and others told me when I announced the first requirement, that encouraged businesses to feel they could come in and demand the same thing of their employees. (more)
Biden then went on to praise companies who are doing it on their own.
…”
Michael,
I did try your link the other night but it said media was to big and took me to chris sky’s telegram fed and could not find it.
Yep, there is definitely concern in the knock on effect to the innate immune system with each jab. Berenson’s chart is definitely a cause for concern. I would liken it to overuse of corticosteroids. From what I know those can also damage the innate immune system. JFK, even though he looked young and healthy, his immune system was quite fragile partly due to cortisone use to control Addison’s disease. I think I understand that correctly. Maybe Dr. John can further clarify or correct our understanding on this.
I’m having trouble finding something that was either posted or linked in the comments. It was an estimation of the number of mRNA instructions (spikes) in a jab. Can anybody help link me to that info? Thanks
My wife knows I’m deep in the weeds in trying to sort this stuff out and she dropped me a video to check out.
wife: “Have you checked it”
me: “Not yet.”
wife: “You really need to. It has immune blood panel info for before, after jab 1 and after jab 2.”
That was Wednesday night.
@WES response last night got me curious about poison ivy and topical IVM. Which led to an article on the immune system and the impact of toxins. To which I noted the following:T-cells participate directly as killer cells against virally infected host cells.
T-cells are long-lived lymphocytes. Some estimates of longevity place some T-cells as existing for 15-20 years.
Since there is little replacement of T-cells, alterations in this compartment may be very detrimental. Lesions in the T-cell system result in enhanced susceptibility to viral, fungal and para-sitic infections and alter the levels of most anti-body responses.
Then @expatkiwi posts a link to Alex Berenson latest. The slope change on that curve is flashing red.
Raul, pens “The Vaxx is Dead, Now What?” Another perfect summary and snapshot of where this train wreck is at/headed.
I finally check out that video my wife sent. The real time stream of consciousness in this community never ceases to amaze me.
https://www.brighteon.com/243f160d-85a5-47b9-bc22-a070cadd8d56
@wdt,
That’s neat. Good to know. Thanks.
thanks, wdt, scrapper,
Let’s try it this way, can a human apply it topically and achieve a therapeutic benefit?
IVM applied topically on the skin, has this been discussed?
I got an email from a coworker about this. Is this alternative way to get it in the system?Yellow buttons. I guess it’s been nearly 90 years but I did not think it was so easily forgotten. What’s happening in Germany and Israel is surreal, let alone Australia.
Back when the local stores were requiring masks and had checkers at the entry, my wife went to a Trader Joe’s in the area. There was a line since they were limiting the number of shoppers in the store. She was maskless and when she got to the entry, they told here to mask up.
She proceeded to school them on the law (as there was no enforceable law where we live). They then told her she would have to push around a cart with a tall flag attached to it. She asked “What is that for?” They said it was so the other shoppers could see her coming over the aisles. She was like, “and yellow stars sewn on my clothes are next?”. They seemed confused, to which she said “Hello, Nazi Germany, concentration camps, WW2.” Not only did she get to shop without mask or a flag, many other shoppers thanked her for standing her ground.
There are only two wills active in the world. Most are unconscious to the one that will kill their soul. Today, I am getting that conscious Jew vibe int the 1930s, today I weep.
John, that was Raul’s genius. I have learned much following the daily links, articles and the commentary provided by you and others.
zerosum,
Crazy as it may seem I do this when I get sick. I stumbled across this many years ago and it works well, but seriously make sure you don’t get blow back in the ear tubes if you attempt this. It’s called the flip turn flush. I have only been on oral antibiotics twice in my life (penicillin for kidney infection in grade school and zpak for sinus infection 20 years ago) Not sure how I would incorporate IVM.
https://www.medhelp.org/user_journals/show/2322/The-Sinus-Flush
Also, following up with Xlear several times a day. This stuff is amazing in my experience.
phoenixvoice,
She is not the real deal which is obvious from her website (I commented to michael reid on this last night). I am ok with her being my nurse but definitely not my doctor. When blood is drawn in a test tube, there is always some liquid chemical in the bottom so that it doesn’t clot on way to the lab. I doubt she even knows that. Anyway here is a proper video on what clotting blood looks like.
Raul, thanks for putting that together. Much appreciated and humbled.
Michael,
Most anybody can use a microscope.
Her qualifications are not even recognized in the her home country of South Africa.
Just a hunch, but I don’t think she is being honest.
Yoh Michael,
I would think Stew would do a better job to prevent from getting punked. “How many surgeries did say she performed in a day in that interview” From her website.
“Please take note that Dr Botha is not a medical Dr but an academic Dr. Her qualification is recognized in 194 countries including America and Europe but not in SA. Dr Botha does not diagnose or treat any illness but supports health through complementary medicine, lifestyle management.”
Germ, triathletes have efficient cardiovascular systems. The velocity of the blood in the capillaries next to the air sacs is low to begin with and in an athlete even lower. The fact that those cells happened to to get painted for destruction by the latent immune response is no surprise to me in the way I have been thinking thru this lately. I think I will keep running with it (pun intended).
zerosum, yep there are others that will see this as raw meat and unpack. I threw it out there in hopes of that. In, the moment, I am trying to piece together other stuff.
Phoenix vice: (the auto complete did that) kinda funny no offense intended. Absolutely, the injections introduce a bit of glycoprotein manufacturing apparatus in to the blood stream. It has a head start over the rest that either stays in the muscle or drains into a nearby lymph node ultimately a fox and hound scenario ensues. The area associated with with all the endothelial cells that make up our vascular system is on the order of a football field. So the damage could occur anywhere. Inflammation, stroke, clots, hamster nuts. Then there is the CNS and it looks Like there is no place that theses chards of glycoproteins can go, Blood brain barrier be damned. Then there is fundamental immune cell-cell communication associated with glycoproteins that in the case of cancer is may also be disrupted.
Mr. House, I get the whole numerator/denominator, jigging relationships to look like hockey sticks instead of plateaus and yes they are lying to build back better or great reset. Or maybe the CCP virus plus uploaded CCP mRNA sequence is a set up for MERS-Cov 2.0. It’s just a thought experiment into unintended or intended consequences and how we may be blind to the outcome. As @Antidote rightly reminds us, “we only see what we look at”
Here is a presentation of a study that focuses on Medicare recipients 65 and over.
https://www.humetrix.com/powerpoint-vaccine.html
My thoughts on Chart 16
In the trials that established the baseline efficacy, people 65 and over weren’t included
Wasn’t there a lawyer that obtained death numbers in the Medicare system of people that died before they were considered fully jabbed up. How would that change this chart if we considered these as breakthroughs infections that were hospitalized?
And Chart 17
Impressive risk reduction for those who previously had Covid and got the jab. Likely, has more to do with natural immunity. This group of people are likely skewing the benefit on the previous chart.
But here is the thing, what if ADE is not a thing and nobody starts melting in their footprint like WTC7. In the limit, as more and more unvaccinated people that have had Covid get jabbed will the efficacy numbers start to inflect making boosters look like they are improving things. I know, Its really natural immunity that’s the driver but the data will be used to give credit to the jab.
Veracious Poet, 38 years ago I was 18 and on track to become a good corporate soldier. No wonder it feels like the Constitution and Bill of Rights are null and void. Your commentary is always appreciated even though the mood elevator can take a hit.
On our way out for a ride tonight, my wife was talking about not having carpets when we move. I said, “Babe, we might have to get used to dirt floors.”
But ya know, I feel a new kind of freedom. Made some new friends with some amazing people that under the old normal I would have never met. My wife’s mom lived with us her last year of life. If it wasn’t for Covid and the locking down of senior care facilities we would have never got that opportunity. Our ride ended with a double rainbow. How many of those do you see in a lifetime.
I am sure Louis experienced the some of the worst aspects of what his fellow man was capable of but yet it brought the best in him for all to enjoy.
We got our “get the jab email” on Friday.
In this email they said that we will follow the law. Sorry, this is not a law. It is an Executive Order from the President. It only covers federal employees under the direct control of the Executive Branch (DHS, DOD, DOJ, etc.). It only applies to those contractors that work directly for the federal government in the Executive Branch controlled agencies. It does NOT apply to privately owned defense contractor companies that have been awarded defense contracts. So our company lawyers are playing it a little loose with wording to force the mandate. That being said, if we ever want to win another US defense contract, the company will do what ever the government recommends, regardless of its ethical or legal standing.
They set the date for Dec. 8th. I don’t think that date is unique to us but was set by the Biden administration. Hey, one day after the Pearl Harbor day. They really want to liken this to a war.
Non-negotiable, never felt so alive.
@Raul “can you turn your research into an article? I can help with the writing if needed”
I would need your help, you have an amazing gift/talent for doing that.
TDK,
Will do, this infection can really set you back making the recovery frustrating. In article [1], the long term impact on WBCs was a new one for me. I haven’t dug too deep here yet. My wife is nearly recovered, still seems to have a bit of walking pneumonia and fatigue. Just got some blood work back and her thyroid was impacted. Big swing towards the hyper end of the range.
The human body is a universe in and of itself and each aspect of it is a galaxy.
In regards to IVM studies.
1) There may be little impact in a respiratory only infection, therefore taking it prophylactically may not help much in the respiratory phase if infected.
2) The real impact seems to be for those whose infections have moved into the vascular system.
Anyway, before addressing the best theory I have come across regarding Covid in the blood I wanted to circle back and highlight the spike proteins RBD affinity to Sialic Acid (SA) and its importance in the human body. Here is the image, showing how this affinity grows from a Corona cold virus thru Sars-Cov2.
Below is from the abstract of the linked paper. (It’s mainly for reference if interested)
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153325/Sialic acid play important roles in human physiology of cell-cell interaction, communication, cell-cell signaling, carbohydrate-protein interactions, cellular aggregation, development processes, immune reactions, reproduction, and in neurobiology and human diseases in enabling the infection process by bacteria and virus, tumor growth and metastasis, microbiome biology, and pathology. It enables molecular mimicry in pathogens that allows them to escape host immune responses.
Viral sialic acid-recognizing lectins or HAs can agglutinate RBC. Viruses use sialic acids linked to glycoproteins and gangliosides to attach to host cells, followed by their entry, for example, corona virus, DNA tumor viruses, hepatitis virus, influenza viruses (A, B, and C), mouse polyoma virus, mumps, Newcastle disease virus (NDV), norovirus, parainfluenza viruses, rotavirus, and Sendai virus. HAs from influenza A, C, NDV, and polyoma viruses have been crystallized. Sialic acid-recognizing lectins from adenoviruses and picornaviruses have not been identified.
Some of these viruses carry neuraminidase or sialyl-O-acetyl-esterase that destroys the receptor, promotes virus release from infected cells, and removes sialic acid on host cell affecting cell surface binding of the virus. Influenza A virus enters the host by using host surface sialic acids. Influenza C virus HA-esterase specific for 9-O-acetylated sialic acids can break down 9-O-acetyl ester. HA-esterase from mouse hepatitis virus is specific to sialic acids substituted by O-acetyl group at the C-4 position (Neu4,5Ac2). HA-neuraminidase of NDV84 and parainfluenza viruses perform vital functions in infection biology
Back in Oct2020, independent researcher David Scheim, uploaded this paper to SSRN. It is not peer reviewed. In virus time it was before the rollout of the jabs and early days of mass IVM awareness. Here is the link to the abstract. From there you can open the pdf.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3706347
Abstract;
The role of vascular occlusion in the morbidities, pulmonary and systemic, of COVID-19 has received increasing focus. Histological studies of lung tissue from COVID-19 patients have found extensively damaged endothelium of capillaries adjoining relatively intact alveoli, corresponding to hypoxemia accompanying normal breathing mechanics in such patients. Advanced image analysis of lung CT scans of COVID-19 patients reveals redistribution of blood flow from smaller to larger diameter blood vessels, this effect correlated with the degree of breathing dysfunction.
Essential to the study of vascular occlusion in COVID-19 are viral properties dating back to studies of Jonas Salk in the 1940s that have been positively established for SARS-CoV-2.
First, SARS-CoV-2 binds to red blood cells (RBCs), in vitro and also clinically in COVID-19 patients.
Second, although fusion and replication of SARS-CoV-2 occur via ACE2, such hemagglutinating viruses initially attach to infective targets and clump with blood cells via much more abundantly distributed sialic acid (SA) glycoconjugate binding sites. SARS-CoV-2, in particular, attaches to these SA sites.
Third, certain enveloped viruses express an enzyme, hemagglutinin esterase (HE), that counteracts viral-RBC clumping. Notably, among betacoronaviruses, the common cold strains express HE while SARS-CoV-2, SARS-CoV-1 and MERS, the virulent strains, do not.
These hemagglutinating properties of SARS-COV-2 establish a framework for “catch and clump” induction of microvascular occlusion proposed here. Ultramicroscopic studies of tissues from COVID-19 patients indicate a key role for hemagglutination early and mid-course in COVID-19, before such clumps harden into clots via the coagulation cascade. Hemagglutination may be reversed by two anti-COVID-19 therapeutics that each competitively bind to SARS-CoV-2 spike protein, blocking such viral attachments. One therapeutic is antiviral antibodies generated by vaccines, the anti-hemagglutination effect of which is exhibited in Jonas Salk’s hemagglutination inhibition assay. The other therapeutic is ivermectin (IVM), a drug of Nobel Prize honored distinction, distributed in 3.7 billion doses worldwide. In ten clinical trials, three with randomized controls, IVM yielded mortality reductions for COVID-19 of 90% at highest doses. IVM may limit virulence of SARS-CoV-2 by steric interference with multivalent spike protein attachments to SA binding sites, blocking hemagglutination, an effect likely to target mutant viral strains.
I had to switch from “be the spike” to “be the Lipid Nano Particle” and I now find myself in a vortex of understanding for which there may be no escape velocity. It could be a kool-aid vortex, but we will see. Suffice it to say, though the primary mechanisms are different, the understanding gained on the infection side is still most useful.
The inflection gains access to the blood stream (“ARDS” like DAD not a precursor)
1) The virus gains access to an epithelial cell in the air sac of the lungs by attaching to ACE2. It uses this cell to make many copies of itself.
2) Once it breaches the epithelial wall, which is only one cell thick it gains access to an ACE2 receptor on the pericytes, which sit on top of the endothelial cells that make up the nearby capillaries.
3) Many more copies are made, weaking the capillary walls, which again are only one cell thick. The virus now has access to the blood stream.Here are three interesting articles, starting with the most recent, describing complications related to having a spike coated virus in the blood.
[1] (virus time = Jul2021)
https://www.dicardiology.com/content/covid-19-changes-properties-blood-cells“Shortness of breath, fatigue and headaches, some patients still struggle with these long-term effects of a severe infection by the SARS-CoV-2 coronavirus after six months or more. This post COVID-19 syndrome, also called COVID long-haulers, is still not properly understood. What is clear is that during the course of the disease, often blood circulation is impaired, clotting and dangerous vascular occlusions can occur, and oxygen transport in is limited. These are all phenomena in which the blood cells and their physical properties play a key role.”
“They found that, for example, the size and deformability of the red blood cells of patients with the disease deviated strongly from those of healthy people. This indicates damage to these cells and could explain the increased risk of vascular occlusion and embolisms in the lungs. In addition, the oxygen supply, which is one of the main tasks of the erythrocytes, may be impaired in infected persons.”
Lymphocytes (one type of white blood cell responsible for the acquired immune defense) were in turn significantly softer in COVID-19 patients, which typically indicates a strong immune reaction. The researchers made similar observations for neutrophil granulocytes, another group of white blood cells involved in the innate immune response. These blood cells even remained drastically altered seven months after the acute infection.
[2] (virus time = Feb2021)
COVID-19 can affect the blood. Its spike protein may be the culprit.
In this article they refer to RGD, I think they mean RBD (Receptor Binding Domain)
The autopsy reports revealed COVID-19 patients were suffering from huge amounts of thick, coagulated blood, and dysfunctional blood vessels were tearing through body tissue instead of repairing it—highly uncommon side effects of respiratory diseases.
The postmortem evidence plus his own experience with something called “COVID toes”—an odd side effect of the disease that causes heightened blood vessel formation in the toes, turning them bright red—led Makowski to speculate that something about the virus might be causing abnormal blood-related complications.
“One of the most perplexing and devastating effects of this disease is the scenario where three or four weeks after being hospitalized with pneumonia, people under the age of 50 are back home, they feel fine, and then all of a sudden they have a stroke and die,” says Makowski, professor and chair of the bioengineering department at Northeastern.
[3] (virus time = Nov2020)
https://news.cuanschutz.edu/news-stories/attack-on-red-blood-cells-a-prime-suspect-in-covids-debilitating-effectsThe oxygen-saturation level of COVID patients, especially those with severe cases, was prone to dropping to dangerous levels, even below 90%. “We asked the question: Can it be due to the cell that transports oxygen?” D’Alessandro said. “Can COVID attack red blood cells – the most abundant cell in the human body – which has evolved specifically to transport oxygen?”
The answer to both questions was “yes.” The study revealed that SARS-CoV-2 damages the membranes of oxygen-carrying red blood cells. The virus didn’t affect the cells’ hemoglobin, which allow the cells to pick up oxygen, but it did damage membrane proteins responsible for blood cell structure, a characteristic that allows these cells to indirectly regulate red cell capacity to release oxygen and, most importantly, to squeeze through narrow capillaries in the periphery of the bloodstream.
“When the red blood cells are damaged, and you’re a COVID patient who is exposed to another stress – pharmacological treatment, high fever or, after recovering from the disease, exercise or something of that nature – then your red blood cell is more likely to hemolyze (rupture),” D’Alessandro said.
This explains why D’Alessandro, who jumped back into training for a late-summer marathon, noticed that more than a month after his initial COVID bout – two subsequent tests came out negative – he felt extremely tired just 20 minutes into a run.
“Something was happening in the red blood cells, and it’s why we believe that they are part of the problem in long-term COVID symptoms,” he said.The lingering oxygen-level difficulties are explained by the lifespan of red blood cells. The cells circulate for up to 120 days before the body replaces them. To make room for hemoglobin, red blood cells have evolved to lose nuclei and organelles that allow other cells to replace damaged molecular components. So, if the virus damages red blood cells, it will be up to four months before they are cleared and replaced with cells that do not carry such damage.
